Dr. Abigail Koppes,
Principal Investigator



Mature enteric neurons have the capacity to reinnervate the intestine with glial cells as their guide
Rhian Stavely, Ahmed A Rahman, Jessica L Mueller, Abigail R Leavitt, Christopher Y Han, Weikang Pan, Kyla N Kaiser, Leah C Ott, Takahiro Ohkura, Richard A Guyer, Alan J Burns, Abigail N Koppes, Ryo Hotta, Allan M Goldstein

Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages. https://doi.org/10.1016/j.engreg.2023.11.003
Francesco Fontana, Andrea Cafarelli, Francesco Iacoponi, Soria Gasparini, Tiziano Pratellesi, Abigail N Koppes, Leonardo Ricotti.


Impact of Non‐Muscle Cells on Excitation‐Contraction Coupling in the Heart and the Importance of In Vitro Models. https://doi.org/10.1002/adbi.202200117
Kirstie Belanger, Abigail N Koppes, Ryan A Koppes.

Complex Material Properties of Gel-Amin: A Transparent and Ionically Conductive Hydrogel for Neural Tissue Engineering. https://doi.org/10.1159/000524692
Katelyn E Neuman, Aidan Kenny, Lily Shi, Abigail N Koppes, Ryan A Koppes.

En route to next-generation nerve repair: static passive magnetostimulation modulates neurite outgrowth. http://doi.org/10.1088/1741-2552/acb103
Katelyn Neuman, Xiaoyu Zhang, Caroline Mills, Ryan Koppes, Laura H Lewis, Abigail Koppes.

A Pumpless, High-Throughput Microphysiological System Confirms Enteric Innervation of Duodenal Epithelium Strengthens the Barrier Function. https://doi.org/10.1101/2023.06.03.543561
Kyla N. Nichols, Jessica R. Snyder, Ryan A. Koppes, Abigail N. Koppes.

Engineered bacteria titrate hydrogen sulfide and induce concentration-dependent effects on host in a gut microphysiological system.
Justin A Hayes, Anna W Lunger, Aayushi S Sharma, Matthew T Fernez, Ryan A Koppes, Abigail N Koppes, Benjamin M Woolston.


Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro. http://doi.org/10.1038/s41598-022-26543-x 
Adam J. Bindas, Kyla N. Nichols, Nicole J. Roth, Ryan Brady, Abigail N. Koppes, Ryan A. Koppes.

Lactate Production can Function to Increase Human Epithelial Cell Iron Concentration. http://doi.org/10.1007/s12195-022-00741-z
Caroline Ghio, Joleen M. Soukup, Lisa A. Dailey, Andrew J. Ghio, Dina M. Schreinemachers, Ryan A. Koppes, Abigail N. Koppes.

Impact of Non-Muscle Cells on Excitation-Contraction Coupling in the Heart and the Importance of In Vitro Models. http://doi.org/10.1002/adbi.202200117
Kirstie Belanger, Abigail N. Koppes, Ryan A. Koppes.

Complex Material Properties of Gel-Amin: A Transparent and Ionically Conductive Hydrogel for Neural Tissue Engineering. http://doi.org/10.1159/000524692
Neuman K.E., Kenny A., Shi L., Koppes A.N., Koppes R.A.

These organoids have some nerve: Uniting three germ layers in a human gastric model system. https://doi.org/10.1016/j.stem.2021.12.005
Kyla N. Nichols, Abigail N. Koppes, Ryan A. Koppes.



Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure. https://doi.org/10.1016/j.ooc.2021.100009
Jonathan R Soucy, Gabriel Burchett, Ryan Brady, Kyla Nichols, David T Breault, Abigail N Koppes, Ryan A Koppes.

Parkinson’s disease and the gut: Models of an emerging relationship. https://doi.org/10.1016/j.actbio.2021.03.071
Adam J. Bindas, Subhash Kulkarni, Ryan A. Koppes, Abigail N. Koppes.

Bioenginneering the neurovascular niche to study the interaction of neural stem cells and endothelial cells. https://doi.org/10.1063/5.0027211
Max A. Winkelman, Abigail N. Koppes, Ryan A. Koppes, and Guohao Dai.

Fund Black scientists. https://doi.org/10.1016/j.cell.2021.01.011
Kelly R. Stevens, Kristyn S.Masters, P. I. Imoukhuede, Karmella A.Haynes, Lori A. Setton, Elizabeth Cosgriff-Hernandez, Muyinatu A. Lediju Bell, Padmini Rangamani, Shelly E. Sakiyama-Elbert, Stacey D. Finley, Rebecca K.Willits, Abigail N. Koppes, Naomi C. Chesler, Karen L. Christman, Josephine B. Allen, Joyce Y. Wong, Hana El-Samad, Tejal A. Desai, Omolola Eniola-Adefeso.



Light irradiation of peripheral nerve cells: Wavelength impacts primary sensory neuron outgrowth in vitro. https://doi.org/10.1016/j.jphotobiol.2020.112105
David Diaz Vera, Jonathan R. Soucy, Audrey Lee, Ryan A. Koppes, Abigail N. Koppes.

Parkinson’s Disease and the Gut: Models of an Emerging Relationship. http://dx.doi.org/10.2139/ssrn.3739626
Bindas, Adam J., Kulkarni, Subhash, Koppes, Ryan A., Koppes, Abigail N.

Innervated adrenomedullary microphysiological system to model prenatal nicotine and opioid exposure. https://doi.org/10.1101/2020.09.22.308973
Jonathan R Soucy, Gabriel Burchett, Ryan Brady, David T Breault, Abigail N Koppes, Ryan A Koppes.

The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro. https://doi.org/10.1002/jnr.24700
Daniel M. Ventre, Avery Cluff, Christian Gagnon, David Diaz Vera, Ryan A. Koppes, Abigail N. Koppes.

Reconfigurable microphysiological systems for modeling innervation and multi-tissue interactions. https://doi.org/10.1002/adbi.202000133
Jon Soucy, Adam Bindas, Ryan Brady, Tess Torregrosa, Cailey Denocourt, Sanjin Hosic, Guohao Dai, Abigail Koppes, Ryan Koppes.

Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury. https://doi.org/10.1007/s12195-020-00633-0
Sanjin Hosic, Will Lake, Eric Stas, Ryan Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes.

Rapid prototyping of multilayer microphysiological systems. https://doi.org/10.1021/acsbiomaterials.0c00190
Sanjin Hosic, Adam Bindas, Marissa L. Puzan, Will Lake, Jonathan Soucy, Fanny Zhou, Ryan A. Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes.

Recent advancements in microphysiological systems for neural development and disease. https://doi.org/10.1016/j.cobme.2020.05.003
Kyla Nichols, Ryan Koppes, Abigail Koppes.

Cryopreservation and functional analysis of cardiac autonomic neurons. https://doi.org/10.1016/j.jneumeth.2020.108724
Tess Torregrosa, Sophie Webster, Chiamaka Aghaizu, Jonathan Soucy, Christopher Bertucci, Leigh Plant, Abigail Koppes, Ryan Koppes.

Materials and Microenvironments for Engineering the Intestinal Epithelium. https://doi.org/10.1007/s10439-020-02470-8
Jessica Snyder, CM Wang, AQ Zhang, Y Li, Josh Luchan, Sanjin Hosic, Ryan Koppes, Rebecca Lyn Carrier, Abigail Koppes.



Glial cells influence cardiac permittivity as evidenced through in vitro and in silico models. doi: 10.1088/1758-5090/ab4c0a
Jonathan R Soucy, Jody Askaryan, David Diaz, Abigail N Koppes, Nasim Annabi, and Ryan A Koppes.

Instrumented Microphysiological Systems for Real-time Measurement and Manipulation of Cellular Electrochemical Processes. https://doi.org/10.1016/j.isci.2019.10.052
Jonathan R. Soucy, Adam J. Bindas, Abigail N. Koppes, and Ryan A. Koppes.

Neural responses to electrical stimulation in 2D and 3D in vitro environments. https://doi.org/10.1016/j.brainresbull.2019.07.016
Christopher Bertucci, Ryan Koppes, Courtney Dumont, and Abigail Koppes.

Stabilized Interleukin-4-Loaded Poly(lactic-co-glycolic) Acid Films Shift Proinflammatory Macrophages toward a Regenerative Phenotype in Vitro. https://doi.org/10.1021/acsabm.8b00769
Alexis M. Ziemba, Anthony R. D’Amato, Taylor M. MacEwen, Devan L. Puhl, Abigail N. Koppes, Ryan A. Koppes, Michelle R. Lennartz, and Ryan J. Gilbert.



Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair. https://doi.org/10.1089/ten.tea.2017.0502
Jonathan R. Soucy, Ehsan Shirzaei Sani, Roberto Portillo Lara, David Diaz, Felipe Dias, Anthony S. Weiss, Abigail N. Koppes, Ryan A. Koppes, and Nasim Annabi.

Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture. https://doi.org/10.1101/400721
Hosic, Sanjin; Puzan, Marissa; Lake, Will; Zhao, Fanny; Koppes, Ryan; Breault, David; Koppes, Abigail.

Glial cells in the heart? Replicating the diversity of the myocardium with low-cost 3D models. https://doi.org/10.1101/306233
Soucy, Jonathan; Askaryan, Jody; Diaz, David; Koppes, Abigail; Annabi, Nasim; Koppes, Ryan.

Enhanced total neurite outgrowth and secondary branching in dorsal root ganglion neurons elicited by low intensity pulsed ultrasound. DOI: 10.1088/1741-2552/aabeba
Ventre, Daniel; Puzan, Marissa; Ashbolt, Emily*; Koppes, Abigail.

Bioactive Organic Rosette Nanotubes Support Sensory Neurite Outgrowth. DOI: 10.1021/acsbiomaterials.8b00326
Puzan, Marissa; Legesse, Belete; Koppes, Ryan; Fenniri, Hicham; Koppes, Abigail.

Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation, Epithelial Monolayer Health, and Inflammation. DOI:10.1038/s41598-018-24768-3
Puzan, Marissa; Hosic, Sanjin; Ghio, Caroline*; Koppes, Abigail.

Photocrosslinkable Gelatin/Tropoelastin Hydrogels for Peripheral Nerve Repair. DOI: 10.1089/ten.TEA.2017.0502
Soucy, Jonathan; Shirzaei Sani, Ehsan; Portillo Lara, Roberto; Diaz, David; Weis, Anthony; Koppes, Abigail; Koppes, Ryan; Annabi; Nasim.



Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties. DOI: 10.1021/acsbiomaterials.8b00135
Spencer, Andrew; Primbetova, Asel; Koppes, Abigail; Koppes, Ryan; Fenniri, Hicham; Annabi, Nasim.

Biology and Engineering of Stem Cell Niches. Chapter 37 – Engineering the Niche for Intestinal Regeneration. doi.org/10.1016/B978-0-12-802734-9.00037-8; ISBN: 978-0-12-802734-9
Victor Hernandez-Gordillo, Abigail N. Koppes, Linda G. Griffith, David T. Breault, Rebecca L. Carrier. Edited by:Ajaykumar Vishwakarma and Jeffrey Karp.



The body acoustic: ultrasonic neuromodulation for translational medicine. DOI: 10.1159/000446622
Daniel M Ventre, Abigail N Koppes.

Complex, multi-scale small intestinal topography replicated in cellular growth substrates fabricated via chemical vapor deposition of Parylene C. doi:10.1088/1758-5090/8/3/035011
Abigail Koppes, Megha Kamath, Courtney Pfluger, Daniel Burkey, Mehmet R Dokmeci, Ling Wang, Rebecca Lyn Carrier.

Robust neurite extension following exogenous electrical stimulation within single walled carbon nanotube-composite hydrogels. doi:10.1016/j.actbio.2016.05.014
AN Koppes, KW Keating, AL McGregor, RA Koppes, KR Kearns, AM Ziemba, CA McKay, JM Zuidema, CJ Rivet, RJ Gilbert, DM Thompson.



Microfluidic Sample Preparation for Single Cell Analysis. doi: 10.1021/acs.analchem.5b04077
Sanjin Hosic, Shashi K Murthy, Abigail N Koppes.

Neural innervation of engineered musculoskeletal tissues. https://doi.org/10.1016/B978-1-78242-301-0.00012-4
AN Koppes, DM Thompson.



Electrical stimuli in the central nervous system microenvironment. DOI: 10.1146/annurev-bioeng-121813-120655
DM Thompson, AN Koppes, JG Hardy, CE Schmidt.

Neurite outgrowth on electrospun PLLA fibers is enhanced by exogenous electrical stimulation. doi:10.1088/1741-2560/11/
AN Koppes, NW Zaccor, CJ Rivet, LA Williams, JM Piselli, RJ Gilbert, DM Thompson.



Electrical stimulation of Schwann cells promotes sustained increases in neurite outgrowth. https://doi.org/10.1089%2Ften.tea.2013.0012
AN Koppes, AL Nordberg, GM Paolillo, NM Goodsell, HA Darwish, L Zhang. DM Thompson.

Neurite outgrowth is significantly increased by the simultaneous presentation of Schwann cells and moderate exogenous electric fields. DOI: 10.1088/1741-2560/8/4/046023
AN Koppes, AM Seggio, DM Thompson.

Single‐walled carbon nanotubes alter Schwann cell behavior differentially within 2D and 3D environments. DOI: 10.1002/jbm.a.32939
BL Behan, DG DeWitt, DR Bogdanowicz, AN Koppes, SS Bale, et al. 

High-performance silicon nanopore hemofiltration membranes. DOI: 10.1016/j.memsci.2008.09.039
WH Fissell, A Dubnisheva, AN Eldridge, AJ Fleischman, AL Zydney, et al. 

Ficoll is not a rigid sphere. DOI: 10.1152/ajprenal.00097.2007
WH Fissell, S Manley, A Dubnisheva, J Glass, J Magistrelli, AN Eldridge, et al. 

Dr. Koppes Invited to Give Keynote at 7th TERMIS World Congress

Dr. Koppes Invited to Give Keynote at 7th TERMIS World Congress

The Principal Investigator of ABNEL, Dr. Abigail Koppes, will be presenting a keynote during this year's TERMIS World Congress. TERMIS is the "Tissue Engineering and Regenerative Medicine International Society". As the name suggests, researchers from around the globe...

Undergraduate Researchers Win Big with PEAK Awards

Undergraduate Researchers Win Big with PEAK Awards

The ABNEL lab could not be prouder of our outstanding group of undergraduate researchers! We have three PEAK award winners: Christina Aniolek (top left) won the Base Camp award, Iris Chang (bottom left) won the Ascent award, and Stephen Landry (right) also won the...