Dr. Abigail Koppes, Principal Investigator



Adam J. Bindas, Kyla N. Nichols, Nicole J. Roth, Ryan Brady, Abigail N. Koppes, Ryan A. Koppes. Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro. http://doi.org/10.1038/s41598-022-26543-x 

Katelyn Neuman, Xiaoyu Zhang, Caroline Mills, Ryan Koppes, Laura H Lewis, Abigail Koppes. En route to next-generation nerve repair: static passive magnetostimulation modulates neurite outgrowth. http://doi.org/10.1088/1741-2552/acb103

Caroline Ghio, Joleen M. Soukup, Lisa A. Dailey, Andrew J. Ghio, Dina M. Schreinemachers, Ryan A. Koppes, Abigail N, Koppes. Lactate Production can Function to Increase Human Epithelial Cell Iron Concentration. http://doi.org/10.1007/s12195-022-00741-z

Kirstie Belanger, Abigail N. Koppes, Ryan A. Koppes. Impact of Non-Muscle Cells on Excitation-Contraction Coupling in the Heart and the Importance of In Vitro Models. http://doi.org/10.1002/adbi.202200117

Neuman K.E., Kenny A., Shi L., Koppes A.N., Koppes R.A.. Complex Material Properties of Gel-Amin: A Transparent and Ionically Conductive Hydrogel for Neural Tissue Engineering. http://doi.org/10.1159/000524692

Kyla N. Nichols, Abigail N. Koppes, Ryan A. Koppes. These organoids have some nerve: Uniting three germ layers in a human gastric model system. https://doi.org/10.1016/j.stem.2021.12.005


Jonathan R Soucy, Gabriel Burchett, Ryan Brady, Kyla Nichols, David T Breault, Abigail N Koppes, Ryan A Koppes. Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure. https://doi.org/10.1016/j.ooc.2021.100009

Adam J. Bindas, Subhash Kulkarni, Ryan A. Koppes, Abigail N. Koppes. Parkinson’s disease and the gut: Models of an emerging relationship. https://doi.org/10.1016/j.actbio.2021.03.071

Max A. Winkelman, Abigail N. Koppes, Ryan A. Koppes, and Guohao Dai. Bioenginneering the neurovascular niche to study the interaction of neural stem cells and endothelial cells. https://doi.org/10.1063/5.0027211

Kelly R. Stevens, Kristyn S.Masters, P. I. Imoukhuede, Karmella A.Haynes, Lori A. Setton, Elizabeth Cosgriff-Hernandez, Muyinatu A. Lediju Bell, Padmini Rangamani, Shelly E. Sakiyama-Elbert, Stacey D. Finley, Rebecca K.Willits, Abigail N. Koppes, Naomi C. Chesler, Karen L. Christman, Josephine B. Allen, Joyce Y. Wong, Hana El-Samad, Tejal A. Desai, Omolola Eniola-Adefeso. Fund Black scientists. https://doi.org/10.1016/j.cell.2021.01.011


David Diaz Vera, Jonathan R. Soucy, Audrey Lee, Ryan A. Koppes, Abigail N. Koppes. Light irradiation of peripheral nerve cells: Wavelength impacts primary sensory neuron outgrowth in vitro. https://doi.org/10.1016/j.jphotobiol.2020.112105

Bindas, Adam J., Kulkarni, Subhash, Koppes, Ryan A., Koppes, Abigail N., Parkinson’s Disease and the Gut: Models of an Emerging Relationship. SSRN Preprint. http://dx.doi.org/10.2139/ssrn.3739626

Jonathan R Soucy, Gabriel Burchett, Ryan Brady, David T Breault, Abigail N Koppes, Ryan A Koppes. Innervated adrenomedullary microphysiological system to model prenatal nicotine and opioid exposure. Biorxiv Preprint. https://doi.org/10.1101/2020.09.22.308973

Daniel M. Ventre, Avery Cluff, Christian Gagnon, David Diaz Vera, Ryan A. Koppes, Abigail N. Koppes. The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro. August 2020. https://doi.org/10.1002/jnr.24700

Jon Soucy, Adam Bindas, Ryan Brady, Tess Torregrosa, Cailey Denocourt, Sanjin Hosic, Guohao Dai, Abigail Koppes, Ryan Koppes. Reconfigurable microphysiological systems for modeling innervation and multi-tissue interactions. July 2020. https://doi.org/10.1002/adbi.202000133

Sanjin Hosic, Will Lake, Eric Stas, Ryan Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes. Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury. June 2020. https://doi.org/10.1007/s12195-020-00633-0

Sanjin Hosic, Adam Bindas, Marissa L. Puzan, Will Lake, Jonathan Soucy, Fanny Zhou, Ryan A. Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes. Rapid prototyping of multilayer microphysiological systems. May 2020. https://doi.org/10.1021/acsbiomaterials.0c00190

Kyla Nichols, Ryan Koppes, Abigail Koppes. Recent advancements in microphysiological systems for neural development and disease. May 2020. https://doi.org/10.1016/j.cobme.2020.05.003

Tess Torregrosa, Sophie Webster, Chiamaka Aghaizu, Jonathan Soucy, Christopher Bertucci, Leigh Plant, Abigail Koppes, Ryan Koppes. Cryopreservation and functional analysis of cardiac autonomic neurons. July 2020. https://doi.org/10.1016/j.jneumeth.2020.108724

Jessica Snyder, CM Wang, AQ Zhang, Y Li, Josh Luchan, Sanjin Hosic, Ryan Koppes, Rebecca Lyn Carrier, Abigail Koppes. Materials and Microenvironments for Engineering the Intestinal Epithelium. Feb 2020. https://doi.org/10.1007/s10439-020-02470-8


Jonathan R Soucy, Jody Askaryan, David Diaz, Abigail N Koppes, Nasim Annabi, and Ryan A Koppes. Glial cells influence cardiac permittivity as evidenced through in vitro and in silico models. Dec 2019. doi: 10.1088/1758-5090/ab4c0a

Jonathan R. Soucy, Adam J. Bindas, Abigail N. Koppes, and Ryan A. Koppes. Instrumented Microphysiological Systems for Real-time Measurement and Manipulation of Cellular Electrochemical Processes. Oct 2019. https://doi.org/10.1016/j.isci.2019.10.052

Christopher Bertucci, Ryan Koppes, Courtney Dumont, and Abigail Koppes. Neural responses to electrical stimulation in 2D and 3D in vitro environments. July 2019. https://doi.org/10.1016/j.brainresbull.2019.07.016

Alexis M. Ziemba, Anthony R. D’Amato, Taylor M. MacEwen, Devan L. Puhl, Abigail N. Koppes, Ryan A. Koppes, Michelle R. Lennartz, and Ryan J. Gilbert. Stabilized Interleukin-4-Loaded Poly(lactic-co-glycolic) Acid Films Shift Proinflammatory Macrophages toward a Regenerative Phenotype in Vitro. Feb 2019. https://doi.org/10.1021/acsabm.8b00769


Jonathan R. Soucy, Ehsan Shirzaei Sani, Roberto Portillo Lara, David Diaz, Felipe Dias, Anthony S. Weiss, Abigail N. Koppes, Ryan A. Koppes, and Nasim Annabi. Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair. Sept 2018. https://doi.org/10.1089/ten.tea.2017.0502

Hosic, Sanjin; Puzan, Marissa; Lake, Will; Zhao, Fanny; Koppes, Ryan; Breault, David; Koppes, Abigail. Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture. bioRxiv 400721; doi: https://doi.org/10.1101/400721. PrePrint (Now Published).

Soucy, Jonathan; Askaryan, Jody; Diaz, David; Koppes, Abigail; Annabi, Nasim; Koppes, Ryan. Glial cells in the heart? Replicating the diversity of the myocardium with low-cost 3D models. bioRxiv 306233; doi: https://doi.org/10.1101/306233. PrePrint (Now Published).

Ventre, Daniel; Puzan, Marissa; Ashbolt, Emily*; Koppes, Abigail. Enhanced total neurite outgrowth and secondary branching in dorsal root ganglion neurons elicited by low intensity pulsed ultrasound. Journal of Neural Engineering. April 2018. DOI: 10.1088/1741-2552/aabeba

Puzan, Marissa; Legesse, Belete; Koppes, Ryan; Fenniri, Hicham; Koppes, Abigail. Bioactive Organic Rosette Nanotubes Support Sensory Neurite Outgrowth. ACS Biomaterials Science & Engineering. March 2018. DOI: 10.1021/acsbiomaterials.8b00326

Puzan, Marissa; Hosic, Sanjin; Ghio, Caroline*; Koppes, Abigail. Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation, Epithelial Monolayer Health, and Inflammation. Scientific Reports. April 2018. DOI:10.1038/s41598-018-24768-3

Soucy, Jonathan; Shirzaei Sani, Ehsan; Portillo Lara, Roberto; Diaz, David; Weis, Anthony; Koppes, Abigail; Koppes, Ryan; Annabi; Nasim. Photocrosslinkable Gelatin/Tropoelastin Hydrogels for Peripheral Nerve Repair. Tissue Engineering A. March 2018. DOI: 10.1089/ten.TEA.2017.0502


Spencer, Andrew; Primbetova, Asel; Koppes, Abigail; Koppes, Ryan; Fenniri, Hicham; Annabi, Nasim. Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties. ACS Biomaterials Science & Engineering. March 2018. DOI: 10.1021/acsbiomaterials.8b00135

Biology and Engineering of Stem Cell Niches. Chapter 37 – Engineering the Niche for Intestinal Regeneration. Victor Hernandez-Gordillo, Abigail N. Koppes, Linda G. Griffith, David T. Breault, Rebecca L. Carrier. Edited by:Ajaykumar Vishwakarma and Jeffrey Karp. doi.org/10.1016/B978-0-12-802734-9.00037-8; ISBN: 978-0-12-802734-9


DM Ventre, AN Koppes. The body acoustic: ultrasonic neuromodulation for translational medicine. Cells, Tissues, Organs. 2015/2016;202:23-41.

Abigail Koppes, Megha Kamath, Courtney Pfluger, Daniel Burkey, Mehmet R Dokmeci, Ling Wang, Rebecca Lyn Carrier. Complex, multi-scale small intestinal topography replicated in cellular growth substrates fabricated via chemical vapor deposition of Parylene C. Biofabrication 8(3): 2016. doi:10.1088/1758-5090/8/3/035011

AN Koppes, KW Keating, AL McGregor, RA Koppes, KR Kearns, AM Ziemba, CA McKay, JM Zuidema, CJ Rivet, RJ Gilbert, DM Thompson. (2016). Robust neurite extension following exogenous electrical stimulation within single walled carbon nanotube-composite hydrogels. Acta biomaterialia 39, 34-43. doi:10.1016/j.actbio.2016.05.014


S Hosic, SK Murthy, AN Koppes (2015) Microfluidic Sample Preparation for Single Cell Analysis. Analytical chemistry 88 (1), 354-380

AN Koppes, DM Thompson. (2015). Neural innervation of engineered musculoskeletal tissues. Regenerative Engineering of Musculoskeletal Tissues and Interfaces, 293


DM Thompson, AN Koppes, JG Hardy, CE Schmidt (2014). Electrical stimuli in the central nervous system microenvironment. Annual review of biomedical engineering 16, 397-430

AN Koppes, NW Zaccor, CJ Rivet, LA Williams, JM Piselli, RJ Gilbert, DM Thompson. (2014). Neurite outgrowth on electrospun PLLA fibers is enhanced by exogenous electrical stimulation. Journal of Neural Engineering, 11. doi:10.1088/1741-2560/11/


AN Koppes, AL Nordberg, GM Paolillo, NM Goodsell, HA Darwish, L Zhang. DM Thompson. (2013). Electrical stimulation of Schwann cells promotes sustained increases in neurite outgrowth. Tissue Engineering Part A, 20 (3-4), 494-506.

AN Koppes, AM Seggio, DM Thompson. (2011). Neurite outgrowth is significantly increased by the simultaneous presentation of Schwann cells and moderate exogenous electric fields. Journal of neural engineering, 8 (4).

BL Behan, DG DeWitt, DR Bogdanowicz, AN Koppes, SS Bale, et al. Single‐walled carbon nanotubes alter Schwann cell behavior differentially within 2D and 3D environments. Journal of Biomedical Materials Research Part A. 96 (1), 46-57

WH Fissell, A Dubnisheva, AN Eldridge, AJ Fleischman, AL Zydney, et al. High-performance silicon nanopore hemofiltration membranes. Journal of membrane science. 326 (1), 58-63

WH Fissell, S Manley, A Dubnisheva, J Glass, J Magistrelli, AN Eldridge, et al. Ficoll is not a rigid sphere. American Journal of Physiology-Renal Physiology. 293 (4), F1209-F1213

Kat and Kyla Succeed at Research Showcase

Kat and Kyla Succeed at Research Showcase

Congratulations to both Kat and Kyla for their performance at today's Research Showcase! The Research Showcase had members from every level of the Chemical Engineering Department (undergraduate to faculty) participating in poster presentations. After the poster...

Jessica Snyder Defends her Thesis

Jessica Snyder Defends her Thesis

On July 31st, Jessica Snyder successfully defended her thesis "Bioengineering the intestinal niche on a chip: investigating signal transmission between the epithelium and enteric neurons". This success has officially earned her the title of doctor. Dr. Snyder has...