Publications
2025
Electrical and magnetic stimulation separately modulates the extent and direction of neurite outgrowth in an ionically conductive hydrogel.
https://doi.org/10.1088/1741-2552/adbb1e
Katelyn Neuman, Xiaoyu Zhang, Bryan Schellberg, Laura H Lewis, Abigail N Koppes, Ryan A Koppes
Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling.
https://doi.org/10.1002/adbi.202300566
Jessica R Snyder, Minhal Ahmed, Sukhada Bhave, Ryo Hotta, Ryan A Koppes, Allan M Goldstein, Abigail N Koppes
Recent advances in integrated organ-chip sensing toward robust and user-friendly systems.
https://doi.org/10.1002/jbm.a.37876
Bryan G Schellberg, Ryan A Koppes, Abigail N Koppes
In situ monitoring of barrier function on-chip via automated, non-invasive luminescence sensing.
https://doi.org/10.1039/D4LC01090F
Bryan G Schellberg, Abigail N Koppes, Ryan A Koppes
Static Magnetic Stimulation and Magnetic Microwires Synergistically Enhance and Guide Neurite Outgrowth.
https://doi.org/10.1002/adhm.202403956
Katelyn Neuman, Xiaoyu Zhang, Brian T Lejeune, Dominic Pizzarella, Manuel Vázquez, Laura H Lewis, Abigail N Koppes, Ryan A Koppes
2024
A call from patient-researchers to advance research on long COVID.
https://doi.org/10.1016/j.cell.2024.09.011
Megan L Fitzgerald, Alison K Cohen, Toni Wall Jaudon, Julia Moore Vogel, Abigail N Koppes, Lucia Santos, Rachel Robles, Jerry Lin, JD Davids, Chris McWilliams, Signe Redfield, Kathleen P Banks, Maria Richardson, Teresa T Tindle Akintonwa, Beth Pollack, Ezra Spier, Aimee Weiss, Gina Assaf, Hannah Davis, Lisa McCorkell
A Pumpless, High-Throughput Microphysiological System Confirms Enteric Innervation of Duodenal Epithelium Strengthens the Barrier Function.
https://doi.org/10.1101/2023.06.03.543561
Kyla N Nichols, Jessica R Snyder, Ryan A Koppes, Abigail N Koppes
Mature enteric neurons have the capacity to reinnervate the intestine with glial cells as their guide.
https://doi.org/10.1016/j.neuron.2024.06.018
Rhian Stavely, Ahmed A Rahman, Jessica L Mueller, Abigail R Leavitt, Christopher Y Han, Weikang Pan, Kyla N Kaiser, Leah C Ott, Takahiro Ohkura, Richard A Guyer, Alan J Burns, Abigail N Koppes, Ryo Hotta, Allan M Goldstein
Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages.
https://doi.org/10.1016/j.engreg.2023.11.003
Francesco Fontana, Andrea Cafarelli, Francesco Iacoponi, Soria Gasparini, Tiziano Pratellesi, Abigail N Koppes, Leonardo Ricotti
2023
Complex Material Properties of Gel-Amin: A Transparent and Ionically Conductive Hydrogel for Neural Tissue Engineering.
https://doi.org/10.1159/000524692
Katelyn E Neuman, Aidan Kenny, Lily Shi, Abigail N Koppes, Ryan A Koppes
En route to next-generation nerve repair: static passive magnetostimulation modulates neurite outgrowth.
http://doi.org/10.1088/1741-2552/acb103
Katelyn Neuman, Xiaoyu Zhang, Caroline Mills, Ryan Koppes, Laura H Lewis, Abigail Koppes
Engineered bacteria titrate hydrogen sulfide and induce concentration-dependent effects on host in a gut microphysiological system.
https://doi.org/10.1101/2023.05.16.538950
Justin A Hayes, Anna W Lunger, Aayushi S Sharma, Matthew T Fernez, Ryan A Koppes, Abigail N Koppes, Benjamin M Woolston
2022
Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro.
http://doi.org/10.1038/s41598-022-26543-x
Adam J. Bindas, Kyla N. Nichols, Nicole J. Roth, Ryan Brady, Abigail N. Koppes, Ryan A. Koppes
Lactate Production can Function to Increase Human Epithelial Cell Iron Concentration.
http://doi.org/10.1007/s12195-022-00741-z
Caroline Ghio, Joleen M. Soukup, Lisa A. Dailey, Andrew J. Ghio, Dina M. Schreinemachers, Ryan A. Koppes, Abigail N. Koppes
Impact of Non-Muscle Cells on Excitation-Contraction Coupling in the Heart and the Importance of In Vitro Models.
http://doi.org/10.1002/adbi.202200117
Kirstie Belanger, Abigail N. Koppes, Ryan A. Koppes
These organoids have some nerve: Uniting three germ layers in a human gastric model system.
https://doi.org/10.1016/j.stem.2021.12.005
Kyla N. Nichols, Abigail N. Koppes, Ryan A. Koppes
2021
Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure.
https://doi.org/10.1016/j.ooc.2021.100009
Jonathan R Soucy, Gabriel Burchett, Ryan Brady, Kyla Nichols, David T Breault, Abigail N Koppes, Ryan A Koppes
Parkinson’s disease and the gut: Models of an emerging relationship.
https://doi.org/10.1016/j.actbio.2021.03.071
Adam J. Bindas, Subhash Kulkarni, Ryan A. Koppes, Abigail N. Koppes
Bioenginneering the neurovascular niche to study the interaction of neural stem cells and endothelial cells.
https://doi.org/10.1063/5.0027211
Max A. Winkelman, Abigail N. Koppes, Ryan A. Koppes, and Guohao Dai
Fund Black scientists.
https://doi.org/10.1016/j.cell.2021.01.011
Kelly R. Stevens, Kristyn S.Masters, P. I. Imoukhuede, Karmella A.Haynes, Lori A. Setton, Elizabeth Cosgriff-Hernandez, Muyinatu A. Lediju Bell, Padmini Rangamani, Shelly E. Sakiyama-Elbert, Stacey D. Finley, Rebecca K.Willits, Abigail N. Koppes, Naomi C. Chesler, Karen L. Christman, Josephine B. Allen, Joyce Y. Wong, Hana El-Samad, Tejal A. Desai, Omolola Eniola-Adefeso
2020
Light irradiation of peripheral nerve cells: Wavelength impacts primary sensory neuron outgrowth in vitro.
https://doi.org/10.1016/j.jphotobiol.2020.112105
David Diaz Vera, Jonathan R. Soucy, Audrey Lee, Ryan A. Koppes, Abigail N. Koppes
The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro.
https://doi.org/10.1002/jnr.24700
Daniel M. Ventre, Avery Cluff, Christian Gagnon, David Diaz Vera, Ryan A. Koppes, Abigail N. Koppes
Reconfigurable microphysiological systems for modeling innervation and multi-tissue interactions.
https://doi.org/10.1002/adbi.202000133
Jon Soucy, Adam Bindas, Ryan Brady, Tess Torregrosa, Cailey Denocourt, Sanjin Hosic, Guohao Dai, Abigail Koppes, Ryan Koppes
Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury.
https://doi.org/10.1007/s12195-020-00633-0
Sanjin Hosic, Will Lake, Eric Stas, Ryan Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes
Rapid prototyping of multilayer microphysiological systems.
https://doi.org/10.1021/acsbiomaterials.0c00190
Sanjin Hosic, Adam Bindas, Marissa L. Puzan, Will Lake, Jonathan Soucy, Fanny Zhou, Ryan A. Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes
Recent advancements in microphysiological systems for neural development and disease.
https://doi.org/10.1016/j.cobme.2020.05.003
Kyla Nichols, Ryan Koppes, Abigail Koppes
Cryopreservation and functional analysis of cardiac autonomic neurons.
https://doi.org/10.1016/j.jneumeth.2020.108724
Tess Torregrosa, Sophie Webster, Chiamaka Aghaizu, Jonathan Soucy, Christopher Bertucci, Leigh Plant, Abigail Koppes, Ryan Koppes
Materials and Microenvironments for Engineering the Intestinal Epithelium.
https://doi.org/10.1007/s10439-020-02470-8
Jessica Snyder, CM Wang, AQ Zhang, Y Li, Josh Luchan, Sanjin Hosic, Ryan Koppes, Rebecca Lyn Carrier, Abigail Koppes
2019
Glial cells influence cardiac permittivity as evidenced through in vitro and in silico models.
https://doi.org/10.1088/1758-5090/ab4c0a
Jonathan R Soucy, Jody Askaryan, David Diaz, Abigail N Koppes, Nasim Annabi, and Ryan A Koppes
Instrumented Microphysiological Systems for Real-time Measurement and Manipulation of Cellular Electrochemical Processes.
https://doi.org/10.1016/j.isci.2019.10.052
Jonathan R. Soucy, Adam J. Bindas, Abigail N. Koppes, and Ryan A. Koppes
Neural responses to electrical stimulation in 2D and 3D in vitro environments.
https://doi.org/10.1016/j.brainresbull.2019.07.016
Christopher Bertucci, Ryan Koppes, Courtney Dumont, and Abigail Koppes
Stabilized Interleukin-4-Loaded Poly(lactic-co-glycolic) Acid Films Shift Proinflammatory Macrophages toward a Regenerative Phenotype in Vitro.
https://doi.org/10.1021/acsabm.8b00769
Alexis M. Ziemba, Anthony R. D’Amato, Taylor M. MacEwen, Devan L. Puhl, Abigail N. Koppes, Ryan A. Koppes, Michelle R. Lennartz, and Ryan J. Gilbert
2018
Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair.
https://doi.org/10.1089/ten.tea.2017.0502
Jonathan R. Soucy, Ehsan Shirzaei Sani, Roberto Portillo Lara, David Diaz, Felipe Dias, Anthony S. Weiss, Abigail N. Koppes, Ryan A. Koppes, and Nasim Annabi
Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture.
https://doi.org/10.1101/400721
Hosic, Sanjin; Puzan, Marissa; Lake, Will; Zhao, Fanny; Koppes, Ryan; Breault, David; Koppes, Abigail
Glial cells in the heart? Replicating the diversity of the myocardium with low-cost 3D models.
https://doi.org/10.1101/306233
Soucy, Jonathan; Askaryan, Jody; Diaz, David; Koppes, Abigail; Annabi, Nasim; Koppes, Ryan
Enhanced total neurite outgrowth and secondary branching in dorsal root ganglion neurons elicited by low intensity pulsed ultrasound.
https://doi.org/10.1088/1741-2552/aabeba
Ventre, Daniel; Puzan, Marissa; Ashbolt, Emily*; Koppes, Abigail
Bioactive Organic Rosette Nanotubes Support Sensory Neurite Outgrowth.
https://doi.org/10.1021/acsbiomaterials.8b00326
Puzan, Marissa; Legesse, Belete; Koppes, Ryan; Fenniri, Hicham; Koppes, Abigail
Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation, Epithelial Monolayer Health, and Inflammation.
https://doi.org/10.1038/s41598-018-24768-3
Puzan, Marissa; Hosic, Sanjin; Ghio, Caroline*; Koppes, Abigail
Photocrosslinkable Gelatin/Tropoelastin Hydrogels for Peripheral Nerve Repair.
https://doi.org/10.1089/ten.TEA.2017.0502
Soucy, Jonathan; Shirzaei Sani, Ehsan; Portillo Lara, Roberto; Diaz, David; Weis, Anthony; Koppes, Abigail; Koppes, Ryan; Annabi; Nasim
2017
Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties.
https://doi.org/10.1021/acsbiomaterials.8b00135
Spencer, Andrew; Primbetova, Asel; Koppes, Abigail; Koppes, Ryan; Fenniri, Hicham; Annabi, Nasim
Biology and Engineering of Stem Cell Niches. Chapter 37 – Engineering the Niche for Intestinal Regeneration.
https://doi.org/10.1016/B978-0-12-802734-9.00037-8
Victor Hernandez-Gordillo, Abigail N. Koppes, Linda G. Griffith, David T. Breault, Rebecca L. Carrier. Edited by:Ajaykumar Vishwakarma and Jeffrey Karp
2016
The body acoustic: ultrasonic neuromodulation for translational medicine.
https://doi.org/10.1159/000446622
Daniel M Ventre, Abigail N Koppes
Complex, multi-scale small intestinal topography replicated in cellular growth substrates fabricated via chemical vapor deposition of Parylene C.
https://doi.org/10.1088/1758-5090/8/3/035011
Abigail Koppes, Megha Kamath, Courtney Pfluger, Daniel Burkey, Mehmet R Dokmeci, Ling Wang, Rebecca Lyn Carrier
Robust neurite extension following exogenous electrical stimulation within single walled carbon nanotube-composite hydrogels.
https://doi.org/10.1016/j.actbio.2016.05.014
AN Koppes, KW Keating, AL McGregor, RA Koppes, KR Kearns, AM Ziemba, CA McKay, JM Zuidema, CJ Rivet, RJ Gilbert, DM Thompson
2015
Microfluidic Sample Preparation for Single Cell Analysis.
https://doi.org/10.1021/acs.analchem.5b04077
Sanjin Hosic, Shashi K Murthy, Abigail N Koppes
Neural innervation of engineered musculoskeletal tissues.
https://doi.org/10.1016/B978-1-78242-301-0.00012-4
AN Koppes, DM Thompson
2014
Electrical stimuli in the central nervous system microenvironment.
https://doi.org/10.1146/annurev-bioeng-121813-120655
DM Thompson, AN Koppes, JG Hardy, CE Schmidt
Neurite outgrowth on electrospun PLLA fibers is enhanced by exogenous electrical stimulation.
https://doi.org/10.1088/1741-2560/11/
AN Koppes, NW Zaccor, CJ Rivet, LA Williams, JM Piselli, RJ Gilbert, DM Thompson
2007-2013
Electrical stimulation of Schwann cells promotes sustained increases in neurite outgrowth.
https://doi.org/10.1089%2Ften.tea.2013.0012
AN Koppes, AL Nordberg, GM Paolillo, NM Goodsell, HA Darwish, L Zhang. DM Thompson
Neurite outgrowth is significantly increased by the simultaneous presentation of Schwann cells and moderate exogenous electric fields.
https://doi.org/10.1088/1741-2560/8/4/046023
AN Koppes, AM Seggio, DM Thompson
Single‐walled carbon nanotubes alter Schwann cell behavior differentially within 2D and 3D environments.
https://doi.org/10.1002/jbm.a.32939
BL Behan, DG DeWitt, DR Bogdanowicz, AN Koppes, SS Bale, et al.
High-performance silicon nanopore hemofiltration membranes.
https://doi.org/10.1016/j.memsci.2008.09.039
WH Fissell, A Dubnisheva, AN Eldridge, AJ Fleischman, AL Zydney, et al.
Ficoll is not a rigid sphere.
https://doi.org/10.1152/ajprenal.00097.2007
WH Fissell, S Manley, A Dubnisheva, J Glass, J Magistrelli, AN Eldridge, et al.
Congratulations on the PhD, Dr. Tori Duback!
Tori's terrific T cells targeted tumors so effectively that today she has earned herself a PhD and the title of "Doctor". Tori joined ABNEL back in the fall of 2022 as a Chemical Engineering Industry PhD student with Sana Biotechnology. While only at Northeastern for...
Bryan Just Keeps Winning – BioEl2025 Student Talk Award
Looking for more of a challenge, ABNEL's PhD student, Bryan Schellberg, headed to Austria to attend the BioEl2025 conference. During this event, Bryan gave a talk titled "In-situ monitoring of cellular function on-chip via automated, non-invasive luminescence sensing"...